Engineering an APRIL-specific B Cell Maturation Antigen
نویسندگان
چکیده
منابع مشابه
Antigen-Specific B Cell Memory
The mechanisms that regulate B cell memory and the rapid recall response to antigen remain poorly defined. This study focuses on the rapid expression of B cell memory upon antigen recall in vivo, and the replenishment of quiescent B cell memory that follows. Based on expression of CD138 and B220, we reveal a unique and major subtype of antigen-specific memory B cells (B220(-)CD138(-)) that are ...
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The development and antigen-dependent differentiation of B lymphocytes are orchestrated by an array of growth factors, cytokines, and chemokines that require tight spatiotemporal regulation. Heparan sulfate proteoglycans specifically bind and regulate the bioavailability of soluble protein ligands, but their role in the immune system has remained largely unexplored. Modification of heparan sulf...
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The CBA/N strain of mouse, derived in 1966 from the C B A / H strain (1), carries an X-linked mutation whose expression affects a number of B-cell functions. The B cells in adult CBA/N mice have many of the characteristics of those found in neonatal mice, including a higher density of surface IgM and a lower expression of B-cell differentiation markers, such as Ia, Mls, Lyb3, and Lyb5.1 (2-5). ...
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The manuscript was withdrawn by the Author.
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A proliferation-inducing ligand (APRIL) is a ligand of the tumor necrosis factor (TNF) family that stimulates tumor cell growth in vitro and in vivo. Expression of APRIL is highly upregulated in many tumors including colon and prostate carcinomas. Here we identify B cell maturation antigen (BCMA) and transmembrane activator and calcium modulator and cyclophilin ligand (CAML) interactor (TACI), ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2004
ISSN: 0021-9258
DOI: 10.1074/jbc.m312316200